Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study.

Richard P McNeillMei ZhangMichael J EptonMatthew P Doogue

Published in: British journal of clinical pharmacology (2021)

Severe COPD is associated with a clinically significant reduction in oral drug clearance. This may be greater for cytochrome P450 substrates than for glucuronidated drugs. This supports reduced starting doses when prescribing for patients with severe COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
drug induced
early onset
primary care
adverse drug
emergency department
high throughput
single cell