Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction.
Daniel GillettRussell SenanayakeJames MacFarlaneMerel van der MeulenOlympia KoulouriAndrew S PowlsonRosy CrawfordBethany GillettNick BirdSarah HeardAngelos KoliasRichard MannionLuigi AlojIosif A MendichovszkyHeok CheowWaiel A BashariMark GurnellPublished in: EJNMMI research (2022)
Met-PET scans should be normalized to the cerebellum to minimize the effects of physiological variation in pituitary gland uptake of 11C-methionine, especially when comparing serial imaging. Subtraction imaging following endocrine suppression of tumor function improved lateralization of PA when compared with single time point clinical Met-PET but, importantly, only if the images were normalized to the cerebellum prior to subtraction.