Inspiratory Muscle Dysfunction Mediates and Predicts a Disease Continuum of Hypercapnic Failure in Chronic Obstructive Pulmonary Disease.
Jens SpiesshoeferSimon D HerkenrathMarcel TremlAnja Pietzke-CalcagnileLars HagmeyerBinaya RegmiSandhya MatthesPeter YoungMatthias BoentertWinfried J RanderathPublished in: Respiration; international review of thoracic diseases (2024)
In COPD, inspiratory muscle dysfunction contributes to progressive hypercapnic failure. In contrast to invasive tests of diaphragm strength only MIP fully reflects the pathophysiological continuum of hypercapnic failure and predicts isolated nocturnal hypercapnia.
Keyphrases
- respiratory failure
- skeletal muscle
- mechanical ventilation
- oxidative stress
- chronic obstructive pulmonary disease
- multiple sclerosis
- blood pressure
- magnetic resonance
- obstructive sleep apnea
- extracorporeal membrane oxygenation
- lung function
- physical activity
- sleep apnea
- depressive symptoms
- computed tomography
- sleep quality