Chaenomeles Fructus (CF), the Fruit of Chaenomeles sinensis Alleviates IL-1β Induced Cartilage Degradation in Rat Articular Chondrocytes.
Changhwan YeoChae Ryeong AhnJai-Eun KimYoung-Woo KimJinbong ParkYeong Shik KimIn Jin HaYoon-Jae LeeSeung-Ho BaekIn Hyuk HaPublished in: International journal of molecular sciences (2022)
Osteoarthritis (OA) causes persistent pain, joint dysfunction, and physical disability. It is the most prevalent type of degenerative arthritis, affecting millions of people worldwide. OA is currently treated with a focus on pain relief, inflammation control, and artificial joint surgery. Hence, a therapeutic agent capable of preventing or delaying the progression of OA is needed. OA is strongly associated with the degeneration of the articular cartilage and changes in the ECM, which are primarily associated with a decrease in proteoglycan and collagen. In the progress of articular cartilage degradation, catabolic enzymes, such as matrix metalloproteinases (MMPs), are activated by IL-1β stimulation. Given the tight relationship between IL-1β and ECM (extra-cellular matrix) degradation, this study examined the effects of Chaenomeles Fructus (CF) on IL-1β-induced OA in rat chondrocytes. The CF treatment reduced IL-1β-induced MMP3/13 and ADAMTS-5 production at the mRNA and protein levels. Similarly, CF enhanced col2a and aggrecan accumulation and chondrocyte proliferation. CF inhibited NF-κB (nuclear factor kappa B) activation, nuclear translocation induced by IL-1β, reactive oxygen species (ROS) production, and ERK phosphorylation. CF demonstrated anti-OA and articular regeneration effects on rat chondrocytes, thus, suggesting that CF is a viable and fundamental therapeutic option for OA.
Keyphrases
- cystic fibrosis
- nuclear factor
- knee osteoarthritis
- oxidative stress
- diabetic rats
- reactive oxygen species
- signaling pathway
- extracellular matrix
- high glucose
- toll like receptor
- stem cells
- rheumatoid arthritis
- minimally invasive
- pain management
- multiple sclerosis
- cell proliferation
- drug induced
- mental health
- blood brain barrier
- acute coronary syndrome
- spinal cord injury
- endothelial cells
- coronary artery disease
- mouse model
- immune response
- coronary artery bypass
- smoking cessation
- amino acid