Nucleus-cytoskeleton communication impacts on OCT4-chromatin interactions in embryonic stem cells.

Juan José RomeroMaría Cecilia De RossiCamila OsesCamila Vázquez EchegarayPaula VerneriMarcos FranciaAlejandra GubermanValeria Levi

Published in: BMC biology (2022)

Our results suggest roles of components of the cytoskeleton in shaping the nucleus of ES cells, influencing the interactions of the transcription factor OCT4 with the chromatin and potentially affecting pluripotency and cell fate.

Keyphrases

embryonic stem cells
transcription factor
cell fate
induced apoptosis
optical coherence tomography
dna damage
gene expression
diabetic retinopathy
cell cycle arrest
dna binding
genome wide
optic nerve
endoplasmic reticulum stress
genome wide identification
cell death
cell proliferation
pi k akt