Association of neurostructural biomarkers with secondary attention-deficit/hyperactivity disorder (ADHD) symptom severity in children with traumatic brain injury: a prospective cohort study.
Nicholas P RyanCathy CatroppaStorm Courtney WardKeith Owen YeatesLouise CrossleyMarisa HollenkampStephen HearpsMiriam H BeauchampVicki A AndersonPublished in: Psychological medicine (2022)
Our prospective study findings suggest that neurostructural alterations within higher-order cognitive circuitry may represent a prospective risk factor for s-ADHD symptomatology at 12-months post-injury in children with TBI. High-resolution structural brain MRI has potential to provide early prognostic biomarkers that may help early identification of high-risk children with TBI who are likely to benefit from early surveillance and preventive measures to optimise long-term neuropsychiatric outcomes.
Keyphrases
- attention deficit hyperactivity disorder
- traumatic brain injury
- autism spectrum disorder
- young adults
- high resolution
- working memory
- magnetic resonance imaging
- severe traumatic brain injury
- mass spectrometry
- type diabetes
- skeletal muscle
- multiple sclerosis
- white matter
- adipose tissue
- insulin resistance
- brain injury
- resting state
- functional connectivity
- weight loss