ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data.

Shuto HayashiRui YamaguchiShinichi MizunoMitsuhiro KomuraSatoru MiyanoHidewaki NakagawaSeiya Imoto

Published in: BMC genomics (2018)

ALPHLARD showed good performance for HLA genotyping even from low-coverage data. It also has a potential to detect rare germline variants and somatic mutations in HLA genes. It would help to fill in the current gaps in HLA reference databases and unveil the immunological significance of somatic mutations identified in HLA genes.

Keyphrases

genome wide
copy number
big data
electronic health record
bioinformatics analysis
dna methylation
genome wide analysis
healthcare
transcription factor
climate change
deep learning
data analysis
human health