Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure.

Huayu YangLejia SunYuan PangDandan HuHaifeng XuShuangshuang MaoWenbo PengYanan WangYiyao XuYong-Chang ZhengShunda DuHaitao ZhaoTianyi ChiXin LuXinting SangShouxian ZhongXin WangHongbing ZhangPengyu HuangWei SunYilei Mao

Published in: Gut (2020)

Our results demonstrated a comprehensive proof of principle, which indicated that 3DP-HO model of liver tissues possessed in vivo hepatic functions and alleviated liver failure after transplantation, suggesting that 3D bioprinting could be used to generate human liver tissues as the alternative transplantation donors for treatment of liver diseases.

Keyphrases

liver failure
hepatitis b virus
gene expression
cell therapy
type diabetes
stem cells
adipose tissue
kidney transplantation
metabolic syndrome
skeletal muscle