DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma.

Yinan ZhengRyan A HladyBrian T JoyceKeith D RobertsonChunyan HeDrew R NanniniWarren A KibbeChad J AchenbachRobert L MurphyLewis R RobertsLifang Hou

Published in: Clinical epigenetics (2019)

Our findings indicate that HCV infection is associated with loss of DNA methylation in specific REs, which could implicate molecular mechanisms in liver cancer development. If our findings are validated in larger sample sizes, methylation of these REs may be useful as an early detection biomarker for HCV-HCC and/or a target for prevention of HCC in HCV-positive individuals.

Keyphrases

dna methylation
hepatitis c virus
genome wide
hepatitis c virus infection
gene expression
human immunodeficiency virus
high glucose
high frequency
diabetic rats
copy number
drug induced