Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.
Anouk von BorstelThi Ho NguyenLouise C RowntreeThomas Myles AshhurstLilith F AllenLauren J HowsonNatasha E HolmesOlivia C SmibertJason A TrubianoClaire L GordonAllen C ChengStephen J KentJamie RossjohnKatherine KedzierskaMartin S DaveyPublished in: Immunology and cell biology (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27 neg CD45RA + CX3CR1 + Vδ1 effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB + Vδ2 + T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1 + or Vδ2 + subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals.
Keyphrases
- respiratory syndrome coronavirus
- coronavirus disease
- sars cov
- liver failure
- drug induced
- regulatory t cells
- dendritic cells
- respiratory failure
- type iii
- aortic dissection
- induced apoptosis
- immune response
- signaling pathway
- peripheral blood
- genetic diversity
- cell proliferation
- oxidative stress
- acute respiratory distress syndrome
- systemic lupus erythematosus
- ankylosing spondylitis
- idiopathic pulmonary fibrosis
- mechanical ventilation