Empirical assessment of case-based methods for identification of drugs associated with acute liver injury in the French National Healthcare System database (SNDS).

Nicolas H ThurinRégis LassalleMartijn SchuemieMarine PénichonJoshua J GagneJeremy A RassenJacques BenichouAlain WeillPatrick BlinNicholas MooreCécile Droz-Perroteau

Published in: Pharmacoepidemiology and drug safety (2020)

SCCS adjusting for multiple drugs and using exposed time as the risk window performed best in generating ALI-related drug safety alert and providing estimates of the magnitude of the risk. This approach may be useful for ad-hoc pharmacoepidemiology studies to support regulatory actions.

Keyphrases

drug induced
liver injury
adverse drug
liver failure
transcription factor
emergency department