Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide.
Molly O'ReillyLaura C SommerfeldChristopher O'SheaSophie Broadway-StringerS AndaleebJasmeet S ReyatSyeeda Nashitha KabirD StastnyAntonia MalinovaD DelbueL FortmuellerKatja GehmlichDavor PavlovicBoris V SkryabinAndrew P HolmesPaulus F KirchhofLarissa FabritzPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
The Scn5a-M1875T point mutation causes gain-of-function of the cardiac sodium channel. Our results suggest increased atrial peak sodium current as a potential trigger for increased atrial excitability.