Partial mGlu 5 receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice.

Agnieszka Pałucha-PoniewieraAnna Rafało-UlińskaMichal SantockiYana BabiiKatarzyna Kaczorowska

Published in: Pharmacological reports : PR (2024)

receptor NAM, M-5MPEP, induced rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhanced (R)-ketamine action in mice, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression as RAAD.

Keyphrases

major depressive disorder
high fat diet induced
high glucose
metabolic syndrome
adipose tissue
oxidative stress
diabetic rats
endothelial cells
wild type