Silica-Based Nanomaterials for Diabetes Mellitus Treatment.
Diogo MarinheiroFátima MartelBárbara J M Leite FerreiraAna Luísa Daniel-da-SilvaPublished in: Bioengineering (Basel, Switzerland) (2022)
Diabetes mellitus, a chronic metabolic disease with an alarming global prevalence, is associated with several serious health threats, including cardiovascular diseases. Current diabetes treatments have several limitations and disadvantages, creating the need for new effective formulations to combat this disease and its associated complications. This motivated the development of therapeutic strategies to overcome some of these limitations, such as low therapeutic drug bioavailability or poor compliance of patients with current therapeutic methodologies. Taking advantage of silica nanoparticle characteristics such as tuneable particle and pore size, surface chemistry and biocompatibility, silica-based nanocarriers have been developed with the potential to treat diabetes and regulate blood glucose concentration. This review discusses the main topics in the field, such as oral administration of insulin, glucose-responsive devices and innovative administration routes.
Keyphrases
- glycemic control
- blood glucose
- type diabetes
- cardiovascular disease
- weight loss
- risk factors
- insulin resistance
- healthcare
- cancer therapy
- public health
- drug delivery
- mental health
- blood pressure
- metabolic syndrome
- risk assessment
- social media
- adipose tissue
- adverse drug
- health information
- coronary artery disease
- replacement therapy