CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function.
Longxin XieJessica MerjaneCristian A BergmannJiazhen XuBryan HurtleChristopher J DonnellyPublished in: bioRxiv : the preprint server for biology (2024)
CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function.CUTS exhibits a significant linear relationship with TDP-43 loss.CUTS can deliver an autoregulated gene payload in response to TDP-43 loss-of-function.TDP-43 homotypic phase transitions induce loss of splicing function via CUTS detection.