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Glial Contributions to Lafora Disease: A Systematic Review.

Stefania Della VecchiaMaria MarcheseFilippo Maria Santorelli
Published in: Biomedicines (2022)
Given the evidence for the role of neuroinflammation in LD, future studies should consider glial cells as a potential therapeutic target for modifying/delaying LD progression; however, it should be kept in mind that these cells can potentially assume multiple reactive phenotypes, which could influence the therapeutic response.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • neuropathic pain
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • oxidative stress
  • risk assessment
  • inflammatory response
  • spinal cord injury
  • spinal cord