Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.
Adam R SmithRebecca G SmithEhsan PishvaEilis HannonJanou A Y RoubroeksJoe BurrageClaire TroakesSafa Al-SarrajCarolyn SloanJonathan MillDaniel L van den HoveKatie LunnonPublished in: Clinical epigenetics (2019)
Our study represents the first epigenome-wide association study of both DNA methylation and hydroxymethylation in Alzheimer's disease entorhinal cortex. We demonstrate that previous estimates of DNA hypermethylation in ANK1 in Alzheimer's disease were underestimates as it is confounded by hypohydroxymethylation.