Login / Signup

Pd(II)-Catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides.

Zi-Jia ChenLing-Jie FanPei-Pei XiePu-Fan QianXinquan HuTao ZhouTimothy M Swager
Published in: Chemical communications (Cambridge, England) (2024)
P -Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd(II)-catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides using cheap commercially available L- p Glu-OH as a chiral ligand. A broad range of P -stereogenic phosphinamides were gained in good yields with high enantioselectivities (33 examples, up to 77% yield, 99% ee) via desymmetrization and kinetic resolution.
Keyphrases
  • room temperature
  • ionic liquid
  • capillary electrophoresis
  • single molecule
  • risk assessment
  • mass spectrometry
  • sewage sludge
  • heavy metals
  • anaerobic digestion