FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis.

Lintao SongLuyao WangYushu HouJie ZhouChuchu ChenXianxi YeWenliya DongHuan GaoYi LiuGuanting QiaoTongtong PanQiong ChenYu CaoFengjiao HuZhiheng RaoYajing ChenYu HanMing-Hua ZhengYongde LuoXiaokun LiYongping ChenZhifeng Huang

Published in: Hepatology (Baltimore, Md.) (2022)

Our study identifies FGF4 as a stress-responsive regulator of liver pathophysiology that acts through an FGFR4-AMPK-Caspase 6 signal pathway, shedding light on strategies for treating NAFLD and associated liver pathologies.

Keyphrases

protein kinase
cell death
induced apoptosis
signaling pathway
skeletal muscle
cancer therapy