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Lumbar to sacral root rerouting to restore bladder function in a feline spinal cord injury model: Urodynamic and retrograde nerve tracing results from a pilot study.

Ornella L Van BaMary F BarbeRomain CaremelShachar AharonyOleg LoutochinLine JacquesMatthew W WoodEkta TiwariGerald F TuiteLysanne CampeauJacques CorcosMichael R Ruggieri
Published in: Neurourology and urodynamics (2018)
L7 to S1 ventral root rerouting below the level of SCT showed successful axonal regrowth to the bladder from the L7 spinal cord segment in all rerouted animals, and induced increased detrusor pressure response to cutaneous stimulation in a subset. This feasibility study paves the way for future animal studies for bladder reinnervation.
Keyphrases
  • spinal cord injury
  • spinal cord
  • neuropathic pain
  • urinary tract
  • high glucose
  • diabetic rats
  • current status
  • drug induced
  • endothelial cells
  • lower urinary tract symptoms