Identification of cell-specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis.
Cameron AdamsNisha NairDarren PlantSuzanne M M VerstappenHong L QuachDiana L QuachAlex CarvidiJoanne NitithamMary NakamuraJonathan GrafAnne BartonLindsey A CriswellLisa F BarcellosPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
We identified cell-specific changes in DNAm associated with MTX response in RA patients. Future studies of DNAm and MTX response should include measurements of DNAm from sorted cells.
Keyphrases
- rheumatoid arthritis
- dna methylation
- single cell
- end stage renal disease
- cell therapy
- nk cells
- newly diagnosed
- induced apoptosis
- disease activity
- ejection fraction
- chronic kidney disease
- prognostic factors
- gene expression
- genome wide
- interstitial lung disease
- ankylosing spondylitis
- low dose
- oxidative stress
- systemic lupus erythematosus
- systemic sclerosis
- case control
- cell proliferation