BNIP3 in Lung Cancer: To Kill or Rescue?
Anna S GorbunovaMaria A YapryntsevaTatiana V DenisenkoElena M TchevkinaPublished in: Cancers (2020)
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.
Keyphrases
- cell death
- cell cycle arrest
- oxidative stress
- papillary thyroid
- healthcare
- protein protein
- endoplasmic reticulum stress
- binding protein
- squamous cell
- anti inflammatory
- genome wide
- heart failure
- gene expression
- amino acid
- small molecule
- left ventricular
- dna methylation
- lymph node metastasis
- spinal cord injury
- copy number
- endoplasmic reticulum
- replacement therapy