A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth.

María Alejandra GleisnerCristián PeredaAndrés TittarelliMariela NavarreteCamila FuentesIgnacio ÁvalosFabian TempioJuan Pablo ArayaMaría Inés BeckerFermín Eduardo GonzálezMercedes Natalia LópezFlavio Salazar-Onfray

Published in: Journal for immunotherapy of cancer (2021)

The therapeutic vaccine TRIMELVax efficiently controls the weakly immunogenic and aggressive B16F10 melanoma tumor growth, prolonging tumor-bearing mice survival even in the absence of ICB. The strong immunogenicity shown by TRIMELVax encourages clinical studies in patients with melanoma.

Keyphrases

skin cancer
single cell
signaling pathway
cell therapy
regulatory t cells
dendritic cells
metabolic syndrome
heat stress
high fat diet induced
mesenchymal stem cells
skeletal muscle