CircSCAPER knockdown attenuates IL-1β-induced chondrocyte injury by miR-127-5p/TLR4 axis in osteoarthritis.

Yuchang Zhang Ping Zhao Sen Li Xiangqian Mu Huaqi Wang

Published in: Autoimmunity (2022)

CircSCAPER silencing protected against IL-1β-induced apoptosis, ECM degradation, inflammation and oxidative stress in chondrocytes via miR-127-5p/TLR4 axis.

Keyphrases

induced apoptosis
oxidative stress
diabetic rats
toll like receptor
inflammatory response
endoplasmic reticulum stress
immune response
signaling pathway
dna damage
ischemia reperfusion injury
extracellular matrix
rheumatoid arthritis
high glucose
nuclear factor
heat shock