Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis.

Yi-Dong Chen Junrong LiShuang LiYiyu ChengXiaoyu FuJiamin LiLiangru Zhu

Published in: International journal of molecular sciences (2023)

Our results suggest that NR1D1 bridges the circadian clock and UC, controlling BNIP3-mediated mitophagy and representing a potential therapeutic target. Its agonist, SR9009, shows promise in UC symptom alleviation.

Keyphrases

ulcerative colitis
nlrp inflammasome
big data
risk assessment
machine learning
human health
patient reported