17β-Oestradiol Protects from Hepatitis C Virus Infection through Induction of Type I Interferon.

Matteo Nazzareno Barbaglia James Michael Harris Artem SmirnovMichela Emma BurloneCristina Rigamonti Mario Pirisi Rosalba Minisini Andrea Magri

Published in: Viruses (2022)

Resulting in viral control and suppression, 17β-oestradiol induces an interferon-mediated antiviral state in hepatocytes. Oestrogen-stimulated cells modulate the immune response through secretion of type I interferon, which can be countered by blocking interferon-alpha/beta receptor alpha signalling.

Keyphrases

dendritic cells
immune response
hepatitis c virus infection
induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress