Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study.

Dennis KühnCarlos MetzFrederik SeilerHolger WehrfritzSophie RothMohammad AlqudrahAndré BeckerHendrik BrachtStefan WagenpfeilMathias HoffmannRobert BalsUlrich HübnerJürgen GeiselPhilipp M LepperSören Leif Becker

Published in: Critical care (London, England) (2020)

ECMO treatment was associated with significantly reduced serum concentrations of specific antibiotics. Future studies are needed to assess the pharmacokinetic characteristics of antibiotics in ICU patients on ECMO support.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
respiratory failure
mechanical ventilation
end stage renal disease
ejection fraction
newly diagnosed
intensive care unit
chronic kidney disease
acute kidney injury
peritoneal dialysis
patient reported outcomes
combination therapy