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The differences between pure and mixed invasive micropapillary breast cancer: the epithelial-mesenchymal transition molecules and prognosis.

Ozden OzResmiye Irmak YuzugulduAyse YaziciDemet Kocatepe CavdarCengiz YılmazMucteba OzturkHilal DuzelDuygu Gurel
Published in: Breast cancer research and treatment (2024)
The selection of a 90% ratio for classifying pure IMPCs revealed significant differences in certain molecular and prognostic parameters between pure and mixed groups. Notably, the involvement of N-cadherin in the epithelial-mesenchymal transition (EMT) process provided crucial insights for predicting OS and DFS while also distinguishing between the two groups. These findings strongly support the notion that the pure IMPC subgroup represents a distinct entity characterized by unique molecular characteristics and behavioral patterns.
Keyphrases
  • epithelial mesenchymal transition
  • transforming growth factor
  • signaling pathway
  • clinical trial
  • single cell