Genetic polymorphisms of heme-oxygenase 1 (HO-1) may impact on acute kidney injury, bronchopulmonary dysplasia, and mortality in premature infants.

David J AskenaziBrian HalloranNeha PatilSusan KeelingBehtash SaeidiRajesh KoralkarNamasivayam Ambalavanan

Published in: Pediatric research (2015)

We did not find an association between the GT(n) tandem repeat of HO-1 and AKI nor BPD/mortality. However, infants with TT genotype of the 413T>A genetic alteration had lower incidence of AKI. Further studies using larger cohorts are needed to better understand these relationships.

Keyphrases

acute kidney injury
cardiac surgery
risk factors
cardiovascular events
pi k akt
type diabetes
copy number
dna methylation
case control
gene expression
cell proliferation