Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway.

Shuang WangCaixia WangXiao LiYuexin HuRui GouQian GuoXin NieJuanjuan LiuLiancheng ZhuBei Lin

Published in: Cancer cell international (2020)

The TRIB3 was highly expressed and promoting the malignant behavior of ovarian cancer cells by activating the MEK-ERK signaling pathway. It was also found to be associated with genetic variations and immune modulators.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
cell proliferation
small molecule
genome wide
copy number
dna methylation
oxidative stress