Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severity.
Cecile F FrampasKatie LongmanMatt SpickHolly-May LewisCatia D S CostaAlex StewartDeborah Dunn-WaltersDanni GreenerGeorge EvettsDebra Jean SkeneDrupad TrivediAndy PittKatherine HollywoodPerdita BarranMelanie J BaileyPublished in: PloS one (2022)
In this exploratory work, we found that saliva metabolomics and in particular amino acids can be capable of separating high severity COVID-19 patients from low severity COVID-19 patients. This expands the atlas of COVID-19 metabolic dysregulation and could in future offer the basis of a quick and non-invasive means of sampling patients, intended to supplement existing clinical tests, with the goal of offering timely treatment to patients with potentially poor outcomes.
Keyphrases
- mass spectrometry
- liquid chromatography
- sars cov
- coronavirus disease
- high resolution mass spectrometry
- end stage renal disease
- high performance liquid chromatography
- capillary electrophoresis
- gas chromatography
- tandem mass spectrometry
- ejection fraction
- amino acid
- high resolution
- chronic kidney disease
- newly diagnosed
- respiratory syndrome coronavirus
- peritoneal dialysis
- prognostic factors
- solid phase extraction
- patient reported outcomes
- metabolic syndrome
- gas chromatography mass spectrometry
- patient reported