Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.

Shiyun FengJiabao JiaGuangchao LvYue Wang

Published in: Archives of biochemistry and biophysics (2023)

In conclusion, ABCB7 knockdown inhibits the TGF-β signaling pathway, inhibits the survival of esophageal cancer cells by inducing cell death, and reverses the EMT process. Targeting ABCB7 or COX7B could be a novel strategy for the treatment of esophageal cancer.

Keyphrases

signaling pathway
transforming growth factor
epithelial mesenchymal transition
cell death
pi k akt
oxidative stress
cell proliferation
drug delivery