Evaluation of HNF1B, KLK3, ELAC2, TMPRSS2-ERG, and CTNNB1 polymorphisms associated with prostate cancer in samples of patients from HUPE-UERJ.

Raphaela Dos Santos MenezesMaria Cristina DornasCarlos Frederico Ferreira CamposDaniela Bouzas RodeiroFabricio Borges CarreretteRomulo Vianna OliveiraBrenda Amaral de SouzaGabriele Alves de Souza CarvalhoIngrid Alexandre de Abreu BritoDayse Aparecida SilvaRonaldo DamiãoLuís Cristóvão Moraes Sobrino Porto

Published in: The Prostate (2023)

Higher frequencies of risk alleles were confirmed in the SNPs, KLK3 rs2735839_A, ELAC2 rs4792311_A, and TMPRSS2 rs12329760_T in patients with Pca. Rs2735839_A was associated with risk of Pca and rs4792311_A with severity and Gleason score of 7(4 + 3) or greater. There is a need for careful observation of rs2735839 and rs4792311 in association with the prostatic biopsy due to the increased risk of Pca.

Keyphrases

prostate cancer
radical prostatectomy
newly diagnosed
gene expression
immune response
inflammatory response
genome wide
nuclear factor
benign prostatic hyperplasia
ultrasound guided