Early post-natal life stress induces permanent adrenocorticotropin-dependent hypercortisolism in male mice.
Gabriele CampanaStefano LoizzoAndrea FortunaRoberto RimondiniZaira MarocciaAlfredo ScillitaniAlberto FalchettiSanti Mario SpampinatoLuca PersaniIacopo ChiodiniPublished in: Endocrine (2021)
These findings show that these specific ES procedures affect the negative glucocorticoid feedback in the pituitary, but not in the hypothalamus, suggesting a novel model of ACTH-dependent hypercortisolism that can be prevented by silencing the POMC gene.