Ciprofloxacin salt and salt co-crystal with di-hydroxy-benzoic acids.

The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo-propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb--oxy-lic acid], a fluoro-quinolone anti-biotic, namely, ciprofloxacin 2,6-di-hydroxy-benzoate salt, C 17 H 19 FN 3 O 3 + ·C 7 H 5 O 4 - , (I), and ciprofloxacin hydro-chloride-3,5-di-hydroxy-benzoic-water (1/1/1), C 17 H 19 FN 3 O 3 + ·Cl - ·C 7 H 6 O 4 ·H 2 O, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected via head-to-tail N-H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di-hydroxy-benzoic acid.