Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.
Keyphrases
- drug release
- cancer therapy
- high intensity
- drug delivery
- magnetic resonance imaging
- resistance training
- ultrasound guided
- contrast enhanced ultrasound
- disease activity
- computed tomography
- bone marrow
- locally advanced
- mesenchymal stem cells
- systemic lupus erythematosus
- stem cells
- combination therapy
- rectal cancer
- smoking cessation
- chronic myeloid leukemia
- water quality