The Antiproliferative Activity of High-Dose Somatostatin Analogs in Gastro-Entero-Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis.

Francesco PanzutoClaudio RicciMaria RinzivilloLudovica MagiMatteo MarascoGiuseppe LambertiRiccardo CasadeiDavide Campana

Published in: Journal of clinical medicine (2022)

Given the limited efficacy of HD-SSA in preventing the disease progression in unresectable GEP-NENs after failure of standard dose SSA, the use of this therapeutic approach is advisable in selected cases when other antiproliferative treatments are not feasible.

Keyphrases

neuroendocrine tumors
high dose
low dose
stem cell transplantation
locally advanced
molecular docking
liver metastases
squamous cell carcinoma