Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation.

Xu XiaoHuiyuan HouVictor LinDaisy HoKyle TranBriana CheAdam MayJiancheng ZhangZhigang LuZhongping LuPeter X Shaw

Published in: Oxidative medicine and cellular longevity (2017)

In the CA-induced rat model, probucol dose dependently improved the ROSC rate, prolonged survival time, alleviated oxidative stress, and improved cardiac function. Such protective effects are possibly through regulations of the KEAP1-NFE2L2 system.

Keyphrases

oxidative stress
cardiopulmonary resuscitation
diabetic rats
cardiac arrest
dna damage
ischemia reperfusion injury
induced apoptosis
high glucose
left ventricular
heat shock
drug induced
atrial fibrillation
signaling pathway
protein kinase