Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease.

Yuanjie HaoTongxing WangYunlong HouXiaoqi WangYujie YinYi LiuNingxin HanYan MaZhen LiYaru WeiWei FengZhen-Hua JiaHui Qi

Published in: Chinese medicine (2023)

LHQK demonstrated therapeutic effects in AECOPD by reducing inflammation, suppressing goblet cell hyperplasia, preventing Club cell transdifferentiation, reducing Muc5ac hypersecretion, and modulating airway mucus homeostasis. These findings support the clinical use of LHQK as a potential treatment for AECOPD.

Keyphrases

single cell
signaling pathway
chronic obstructive pulmonary disease
oxidative stress
respiratory failure
liver failure
stem cells
intensive care unit
drug induced
combination therapy
bone marrow