The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?
Shirin SadighparvarFereshteh TaleParviz ShahabiSomayyeh NaderiFirouz Ghaderi PakdelPublished in: Basic and clinical neuroscience (2019)
The dual effects of intracerebroventricular bupropion on the VTA dopaminergic neurons but solo inhibitory effect of its microiontophoretic application reflect the intra-VTA and extra-VTA heterogenic cellular and molecular control over the dopaminergic outflow that can be mediated by different receptors. The dopamine autoreceptors on the VTA dopaminergic neurons have complex modulatory effects on the dopaminergic response.