Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression.

Sushree Shankar PandaChi-Chiu LeeKhamushavalli GeevimaanKai-Chi ChenShung-Haur YangChia-Ning ShenWei-Chun HuangFuHan-Chung Wu

Published in: Journal of biomedical science (2024)

This study uncovers relevant functions of EpCAM where Wnt receptors are upregulated via the transcriptional co-factor activity of EpICD. The resultant enhancement of Wnt signaling induces γ-secretase activity further stimulating EpICD cleavage and its nuclear translocation. Our humanized anti-EpCAM antibody hEpAb2-6 blocks these mechanisms and may thereby provide therapeutic benefit in CRC.

Keyphrases

cell adhesion
circulating tumor cells
stem cells
cell proliferation
transcription factor
gene expression
escherichia coli
dna binding
pseudomonas aeruginosa
cystic fibrosis
binding protein
heat stress