AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients.

Lucía NúñezGrecia M Marrón-LiñaresMaría G Crespo-LeiroEduardo Barge-CaballeroEloy Álvarez-LópezNatalia Suarez-FuentetajaMaría Jesús Paniagua-MartinJorge PomboJavier MuñizCarmela D TanE René RodríguezJosé Manuel Vázquez-RodríguezManuel Hermida-Prieto

Published in: PloS one (2019)

We can conclude that polymorphisms in genes related to the biology of B-cells could have an important role in the development of AMR. In fact, the AGT haplotype in ITGA4 gene could potentially increase the risk of AMR.

Keyphrases

genome wide
end stage renal disease
genome wide identification
copy number
ejection fraction
newly diagnosed
chronic kidney disease
heart failure
prognostic factors
peritoneal dialysis
genome wide analysis
patient reported outcomes
gene expression
patient reported
drug induced