Analysis of urinary exosomal metabolites identifies cardiovascular risk signatures with added value to urine analysis.
Marta AgudiezPaula J MartinezMarta Martin-LorenzoAngeles HerederoAranzazu Santiago-HernandezDolores MoleroJuan Manuel Garcia-SeguraGonzalo Aldamiz-EchevarriaGloria Álvarez-LlamasPublished in: BMC biology (2020)
We set up a novel methodology to analyze metabolic alterations in urinary exosomes and identified a cardiometabolic signature in these microvesicles. This study constitutes the first evidence of a role for the exosomal metabolism in CVD and demonstrates the possibility to evaluate the urinary exosomal metabolic content by NMR and MS.