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Analysis of urinary exosomal metabolites identifies cardiovascular risk signatures with added value to urine analysis.

Marta AgudiezPaula J MartinezMarta Martin-LorenzoAngeles HerederoAranzazu Santiago-HernandezDolores MoleroJuan Manuel Garcia-SeguraGonzalo Aldamiz-EchevarriaGloria Álvarez-Llamas
Published in: BMC biology (2020)
We set up a novel methodology to analyze metabolic alterations in urinary exosomes and identified a cardiometabolic signature in these microvesicles. This study constitutes the first evidence of a role for the exosomal metabolism in CVD and demonstrates the possibility to evaluate the urinary exosomal metabolic content by NMR and MS.
Keyphrases
  • ms ms
  • genome wide
  • magnetic resonance
  • multiple sclerosis
  • stem cells
  • mesenchymal stem cells
  • mass spectrometry
  • high resolution
  • dna methylation
  • solid state