Hylan G-F20 and galactomannan joint flares are associated to acute synovitis and release of inflammatory cytokines.

Rodolfo de Melo NunesPablyana Leila Rodrigues CunhaAna Carolina Matias Dinelly PintoVirgínia Claudia Carneiro GirãoJudith Pessoa de Andrade FeitosaFrancisco Airton Castro Rocha

Published in: Advances in rheumatology (London, England) (2020)

Intra-articular injection of HY or GM promote acute transient synovitis whilst not provoking detectable significant joint damage. Local administration of these polysaccharides induces acute intra-articular release of inflammatory cytokines, which may account for joint flares following viscosupplementation.

Keyphrases

liver failure
respiratory failure
drug induced
aortic dissection
oxidative stress
hepatitis b virus
intensive care unit
acute respiratory distress syndrome