Cationic Glycopolymers with Aggregation-Induced Emission for the Killing, Imaging, and Detection of Bacteria.
Die LiJing ChenMei HongYan WangDavid M HaddletonGuang-Zhao LiQiang ZhangPublished in: Biomacromolecules (2021)
Cationic glycopolymers with structures similar to those of typical poly(ionic liquid)s (PILs) were synthesized via the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized d-mannose and tetraphenylethylene units. Such postpolymerization modification provided PILs with aggregation-induced emission effect as well as specific carbohydrate-protein recognition with lectins such as concanavalin A. The interactions between cationic glycopolymers and different microorganisms, including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, were used for the killing, imaging, and detection of bacteria. Besides, these sugar-containing PILs showed a relatively low hemolysis rate due to the presence of saccharide units, which may have potential application in the field of biomaterials.
Keyphrases
- gram negative
- ionic liquid
- multidrug resistant
- high resolution
- escherichia coli
- staphylococcus aureus
- loop mediated isothermal amplification
- label free
- real time pcr
- biofilm formation
- quantum dots
- fluorescence imaging
- pseudomonas aeruginosa
- binding protein
- cystic fibrosis
- solid state
- amino acid
- mass spectrometry
- oxide nanoparticles