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Decrease of spermatozoa with an unbalanced chromosome content after cell sorting in men carrying a structural chromosomal abnormality.

S El FekihC TousN GueganicF BrugnonH Ben AliLouis BujanN MoinardE Caire-TetauruM AjinaN Douet-GuilbertF MorelA Perrin
Published in: Andrology (2019)
Magnetic-activated cell separation is a promising tool for increasing the selection of healthy spermatozoa, with a decrease in the number of spermatozoa with externalization of phosphatidylserine, DNA fragmentation, and chromosome unbalance, for use in assisted reproductive technologies such as intracytoplasmic sperm injection for males with a chromosomal structural abnormality.
Keyphrases
  • copy number
  • single cell
  • cell therapy
  • stem cells
  • circulating tumor
  • single molecule
  • dna methylation
  • gene expression
  • high resolution
  • ultrasound guided
  • nucleic acid