Influence of growth hormone therapy on the occurrence of a second neoplasm in survivors of childhood cancer.

Cécile Thomas-TeinturierIsabelle Oliver-PetitHelene PacquementBrice FresneauRodrigue Sétchéou AllodjiCristina VeresStephanie BolleDelphine BercheryCharlotte Demoor-GoldschmidtNadia HaddyIbrahima DialloFlorent de Vathaire

Published in: European journal of endocrinology (2020)

This study confirms the overall safety of GH use in survivors of childhood cancer, which does not increase the risk of a SN. The slight excess in the risk of meningioma in patients with long-term GH treatment is non-significant and could be due to difficulties in adjustment on cranial radiation volume/dose and/or undiagnosed meningioma predisposing conditions.

Keyphrases

childhood cancer
growth hormone
young adults
risk assessment
low grade
radiation induced
mesenchymal stem cells
combination therapy
bone marrow
smoking cessation