Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Kristiana XhimaJulie OttoyErin GibsonKatherine ZukotynskiChristopher ScottGinelle J FelicianoSabrina AdamoPhillip H KuoMichael J BorrieHoward ChertkowRichard FrayneRobert LaforceMichael D NoseworthyFrank S PratoDemetrios J SahlasEric E SmithVesna SossiAlexander ThielJean-Paul SoucyJean-Claude TardifMaged GoubranSandra E BlackJoel Ramireznull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease-specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
temporal lobe epilepsy
mild cognitive impairment
blood brain barrier