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Glycaemic control and insulin therapy are significant confounders of the obesity paradox in patients with heart failure and diabetes mellitus.

Hanna FröhlichAnna BossmeyerSyed KazmiKevin M GoodeStefan AgewallDan AtarMorten GrundtvigNorbert FreyJohn G F ClelandLutz FrankensteinAndrew L ClarkTobias Täger
Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
In patients with HFrEF, a higher BMI is associated with better survival irrespective of concomitant DM. However, insulin treatment and poor glycaemic control make the relationship much weaker.
Keyphrases
  • type diabetes
  • glycemic control
  • insulin resistance
  • weight gain
  • metabolic syndrome
  • body mass index
  • weight loss
  • stem cells
  • adipose tissue
  • mesenchymal stem cells
  • high fat diet induced
  • cell therapy