Ex vivo radiosensitivity is increased in non-cancer patients taking valproate.
Jenny StritzelbergerJennifer LainerStefanie GollwitzerWolfgang GrafTina JostJohannes D LangTamara M MuellerStefan SchwabRainer FietkauHajo M HamerLuitpold DistelPublished in: BMC neurology (2020)
In our study, we confirmed that patients treated with VPA had an increased radiosensitivity compared to the control group. This could be considered in patients taking VPA prior to the beginning of radiotherapy to avoid toxic side effects of VPA-treatment.